Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.62 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229513 | 0.90 | GSK3B (0.66) | LMNAPTPN7DUSP3GSK3BMEN1 | |
| SCHEMBL13986988 | 0.88 | LMNA (0.59) | LMNAPTPN7DUSP3GSK3BMEN1 | |
| SCHEMBL13986957 | 0.87 | GSK3B (0.56) | LMNAPTPN7DUSP3GSK3BKMT2A | |
| SCHEMBL13986976 | 0.86 | P2RX7 (0.63) | LMNAPTPN7DUSP3GSK3BMEN1 | |
| SCHEMBL13986983 | 0.85 | GSK3B (0.64) | LMNAPTPN7DUSP3GSK3BMEN1 | |
| Trifluoroacetic Acid SCHEMBL5660802 | 0.84 | GSK3B (0.61) | LMNAPTPN7DUSP3GSK3BKMT2A | |
| SCHEMBL10063248 | 0.83 | LMNA (0.56) | LMNAPTPN7DUSP3MEN1KMT2A | |
| SCHEMBL13986950 | 0.82 | GSK3B (0.59) | GSK3BMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13986962 | 0.82 | CYP1A2 (0.55) | GSK3BKMT2APARP1MAPTALDH1A1 | |
| SCHEMBL13986946 | 0.82 | MAPT (0.52) | LMNAPTPN7DUSP3GSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |