Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 8/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1522723 | 0.79 | KMT2A (0.56) | KMT2AFEN1ERCC5 | |
| SCHEMBL1523552 | 0.78 | FEN1 (0.33) | KMT2AFEN1ERCC5GAATSHR | |
| SCHEMBL4716880 | 0.77 | FEN1 (0.41) | FEN1ERCC5GRIK1GRIA1 | |
| SCHEMBL2344052 | 0.76 | FEN1 (0.47) | FEN1ERCC5MAPT | |
| SCHEMBL1522285 | 0.76 | ALDH1A1 (0.39) | KMT2AFEN1GAAMAPTELANE | |
| SCHEMBL1522918 | 0.75 | LMNA (0.39) | KMT2AFEN1GAAMAPTELANE | |
| SCHEMBL1523122 | 0.75 | KMT2A (0.36) | KMT2AFEN1ERCC5GAAMAPT | |
| SCHEMBL1522571 | 0.75 | ALDH1A1 (0.41) | KMT2AGAAUSP2HPGDTSHR | |
| SCHEMBL1522863 | 0.74 | FEN1 (0.54) | KMT2AFEN1ERCC5 | |
| SCHEMBL1522821 | 0.73 | ALDH1A1 (0.36) | KMT2AFEN1GAAELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462620-B2 | Pyrimidinone derivatives and their use in the treatment of atherosclerosis | SMITHKLINE BEECHAM, PLC (GB) | 2008-12-09 | — | — | US | disclosed |