Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215086 | 0.77 | HSD17B10 (0.48) | KDM4EHPGDHSD17B10GAAALDH1A1 | |
| SCHEMBL2736485 | 0.75 | KDM4E (0.47) | KDM4EHPGDHSD17B10GAAALDH1A1 | |
| SCHEMBL17271403 | 0.69 | ATAD2 (0.44) | GAAMCL1HTTALDH1A1LMNA | |
| SCHEMBL9589819 | 0.67 | KDM4E (0.50) | KDM4EHPGDHSD17B10GAAPDE5A | |
| SCHEMBL15478582 | 0.67 | HSD17B10 (0.56) | KDM4EHPGDHSD17B10GAAALDH1A1 | |
| SCHEMBL16279674 | 0.66 | PTGS2 (0.39) | KDM4EHPGDCYP1A2ALDH1A1MAPT | |
| SCHEMBL601768 | 0.64 | PTGS2 (0.35) | KDM4EGAAMCL1HTTPDE5A | |
| SCHEMBL13129669 | 0.63 | PTGS2 (0.37) | KDM4EHPGDHSD17B10CYP1A2PDE5A | |
| SCHEMBL10929464 | 0.63 | ESR1 (0.38) | KDM4EHPGDCYP1A2ALDH1A1PTGS2 | |
| SCHEMBL10909753 | 0.62 | PTGS2 (0.37) | KDM4EHPGDALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312292-A1 | Antipruritics | YASUI KIYOSHI | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312292-A1 | Antipruritics | CNR1, CNR2, OPRL1 | KDM4E 3245/4885HPGD 724/4885HSD17B10 3418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.