SCHEMBL13993752

SCHEMBL13993752

CCCC(=O)Oc1cc2c(cc1OC)OC(C)(C)CC2

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 1/20 0.42
BCHE P06276 1/20 0.42
COXFA4 O00483 1/20 0.42
PDE4D Q08499 1/20 0.41
HSP90AA1 P07900 2/20 0.41
POLB P06746 1/20 0.41
KMT2A Q03164 4/20 0.40
MALT1 Q9UDY8 1/20 0.40
NFKB1 P19838 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
MEN1 O00255 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13993758 0.90 BCHE (0.44) PDE10ABCHECOXFA4PDE4DHSP90AA1
SCHEMBL13993749 0.84 COXFA4 (0.46) PDE10ABCHECOXFA4PDE4DHSP90AA1
SCHEMBL577986 0.82 BCHE (0.49) PDE10ABCHECOXFA4PDE4DHSP90AA1
SCHEMBL13993755 0.79 COXFA4 (0.48) PDE10ABCHECOXFA4PDE4DHSP90AA1
SCHEMBL12569163 0.78 KMT2A (0.44) PDE10ACOXFA4PDE4DHSP90AA1POLB
SCHEMBL13993759 0.78 BCHE (0.43) PDE10ABCHECOXFA4PDE4DHSP90AA1
SCHEMBL546720 0.76 HSP90AA1 (0.42) BCHECOXFA4PDE4DHSP90AA1POLB
SCHEMBL546699 0.76 HSP90AA1 (0.42) BCHECOXFA4PDE4DHSP90AA1POLB
SCHEMBL545891 0.76 PDE4B (0.43) PDE10ABCHECOXFA4PDE4DMALT1
SCHEMBL11156631 0.75 BCHE (0.44) PDE10ABCHECOXFA4PDE4DHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008152159-A2 6 -ACYLOXY- 7-METH0XY- 2, 2 -DIMETHYLCHROMANE COMPOUNDS AND THEIR USE AS PIGMENTATION-REGULATORS LIPOTEC, S.A. (ES) 2008-12-18 WO disclosed