Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 13/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996536 | 0.88 | EGFR (0.48) | CD38EGFRDYRK1ABRD4CREBBP | |
| SCHEMBL13996617 | 0.83 | CD38 (0.53) | CD38EGFRDYRK1ABRD4CREBBP | |
| SCHEMBL13994016 | 0.79 | CD38 (0.47) | CD38EGFRBRD4RET | |
| SCHEMBL18797672 | 0.78 | NQO2 (0.61) | BRD4CREBBPJAK3 | |
| SCHEMBL3660171 | 0.76 | NQO2 (0.48) | CD38EGFRDYRK1ABRD4CREBBP | |
| SCHEMBL13994028 | 0.76 | PRMT6 (0.51) | — | |
| SCHEMBL17806501 | 0.76 | KIF11 (0.54) | CD38EGFRDYRK1ADYRK2DYRK1B | |
| SCHEMBL9289353 | 0.75 | CD38 (0.53) | CD38EGFRDYRK1ADYRK2DYRK1B | |
| SCHEMBL13994046 | 0.75 | IMPDH2 (0.46) | CD38RETIMPDH2IMPDH1 | |
| SCHEMBL13994042 | 0.74 | CYP2A6 (0.50) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |