Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5008183 | 0.89 | MET (0.45) | KDM4EMETKDRTP53MAPT | |
| SCHEMBL5010250 | 0.89 | KIT (0.53) | KITCCNT1CDK9TBK1MKNK1 | |
| SCHEMBL5002057 | 0.88 | CCNT1 (0.49) | KITCCNT1CDK9TBK1MKNK1 | |
| SCHEMBL13994079 | 0.86 | CDK9 (0.47) | KITCCNT1CDK9TBK1MKNK1 | |
| SCHEMBL13994061 | 0.86 | CCNT1 (0.55) | KITCCNT1CDK9TBK1MKNK1 | |
| SCHEMBL13994075 | 0.86 | CCNT1 (0.49) | KITCCNT1CDK9TBK1MKNK1 | |
| SCHEMBL5008373 | 0.85 | CCNT1 (0.48) | KITCCNT1CDK9TBK1MKNK1 | |
| SCHEMBL5005389 | 0.84 | CCNT1 (0.48) | KITCCNT1CDK9TBK1MKNK1 | |
| SCHEMBL13994080 | 0.84 | CCNT1 (0.49) | KITCCNT1CDK9TBK1MKNK1 | |
| SCHEMBL13994139 | 0.84 | CCNT1 (0.48) | KITCCNT1CDK9TBK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |