Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12809357 | 1.00 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDRECQLMAPK1 | |
| SCHEMBL1399760 | 0.90 | DGAT1 (0.40) | ALDH1A1MAPTHPGDRECQLMAPK1 | |
| SCHEMBL1399762 | 0.90 | DGAT1 (0.40) | ALDH1A1MAPTHPGDRECQLMAPK1 | |
| SCHEMBL4253540 | 0.89 | DGAT1 (0.39) | DGAT1NPC1 | |
| SCHEMBL4253536 | 0.89 | DGAT1 (0.39) | DGAT1NPC1 | |
| SCHEMBL1399740 | 0.86 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDRECQLMAPK1 | |
| SCHEMBL1399743 | 0.86 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDRECQLMAPK1 | |
| SCHEMBL1399612 | 0.85 | MAPT (0.37) | ALDH1A1MAPTHPGDRECQLMAPK1 | |
| SCHEMBL1399610 | 0.85 | MAPT (0.37) | ALDH1A1MAPTHPGDRECQLMAPK1 | |
| SCHEMBL1399622 | 0.79 | NPC1 (0.37) | ALDH1A1MAPTMAPK1DGAT1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035417-B1 | BENZIMIDAZOLES AND THEIR USE FOR THE TREATEMNT OF DIABETES | ASTRAZENECA AB (SE) | 2011-03-02 | — | — | EP | disclosed |