Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1399620 | 1.00 | NPC1 (0.37) | NPC1HCAR3ALDH1A1DGAT1MAPT | |
| SCHEMBL4253536 | 0.81 | DGAT1 (0.39) | NPC1HCAR3DGAT1 | |
| SCHEMBL4253540 | 0.81 | DGAT1 (0.39) | NPC1HCAR3DGAT1 | |
| SCHEMBL1399591 | 0.79 | ALDH1A1 (0.39) | NPC1ALDH1A1DGAT1MAPTMAPK1 | |
| SCHEMBL12809357 | 0.79 | ALDH1A1 (0.39) | NPC1ALDH1A1DGAT1MAPTMAPK1 | |
| SCHEMBL3545133 | 0.78 | KDM4E (0.47) | ALDH1A1DGAT1MAPTMAPK1 | |
| SCHEMBL1399740 | 0.77 | ALDH1A1 (0.39) | NPC1ALDH1A1MAPTMAPK1RAB9A | |
| SCHEMBL1399743 | 0.77 | ALDH1A1 (0.39) | NPC1ALDH1A1MAPTMAPK1RAB9A | |
| SCHEMBL1399586 | 0.76 | KMT2A (0.37) | NPC1HCAR3ALDH1A1MAPTMAPK1 | |
| SCHEMBL1399589 | 0.76 | KMT2A (0.37) | NPC1HCAR3ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035417-B1 | BENZIMIDAZOLES AND THEIR USE FOR THE TREATEMNT OF DIABETES | ASTRAZENECA AB (SE) | 2011-03-02 | — | — | EP | disclosed |