Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10613155 | 0.77 | AOC3 (0.52) | LOXL2ARAOC3ALOX5KDM4E | |
| SCHEMBL8960945 | 0.77 | DAO (0.49) | LOXL2ARAOC3KDM4EALDH1A1 | |
| SCHEMBL28061062 | 0.76 | BRD4 (0.51) | LOXL2ARAOC3KDM4EALDH1A1 | |
| SCHEMBL27907181 | 0.73 | SLC6A4 (0.61) | SLC6A2SLC6A4SLC6A3ALDH1A1MAPK1 | |
| SCHEMBL11709440 | 0.73 | AR (0.64) | LOXL2ARAOC3ALOX5KDM4E | |
| SCHEMBL6824543 | 0.71 | AR (0.49) | LOXL2ARAOC3KDM4EALDH1A1 | |
| SCHEMBL30990546 | 0.69 | AOC3 (0.52) | LOXL2ARAOC3ALOX5KDM4E | |
| SCHEMBL9328485 | 0.69 | AOC3 (0.52) | LOXL2ARAOC3ALOX5KDM4E | |
| SCHEMBL28283441 | 0.69 | LOXL2 (0.53) | LOXL2AOC3KDM4EALDH1A1MAPT | |
| SCHEMBL17618004 | 0.68 | KDM4E (0.58) | LOXL2KDM4EALDH1A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1860100-B1 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | LUNDBECK & CO AS H (DK) | 2011-03-02 | — | — | EP | disclosed |
| EP-1860100-A3 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | H. Lundbeck A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| EP-1860100-A2 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRI | H. Lundbeck A/S (DK) | 2007-11-28 | — | — | EP | disclosed |