Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294089 | 0.86 | RAB9A (0.64) | RAB9APOLBNR4A1MAPTL3MBTL1 | |
| SCHEMBL14781004 | 0.84 | AR (0.42) | RAB9APOLBNR4A1MAPTMEN1 | |
| SCHEMBL1901172 | 0.80 | ALDH1A1 (0.76) | RAB9APOLBNR4A1MAPTL3MBTL1 | |
| SCHEMBL19286578 | 0.79 | POLB (0.37) | RAB9APOLBNR4A1MAPTL3MBTL1 | |
| SCHEMBL11654042 | 0.78 | MEN1 (0.55) | RAB9APOLBNR4A1MAPTL3MBTL1 | |
| SCHEMBL16152763 | 0.78 | AR (0.38) | RAB9APOLBNR4A1MAPTMEN1 | |
| SCHEMBL12655113 | 0.77 | POLB (0.57) | RAB9APOLBNR4A1MAPTL3MBTL1 | |
| SCHEMBL28829520 | 0.77 | L3MBTL1 (0.55) | RAB9APOLBNR4A1MAPTL3MBTL1 | |
| SCHEMBL13996668 | 0.77 | NPC1 (0.50) | RAB9APOLBMAPTMEN1KMT2A | |
| SCHEMBL11653163 | 0.76 | L3MBTL1 (0.54) | RAB9APOLBNR4A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |