Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11280400 | 0.84 | TRPA1 (0.61) | TRPA1MAOAMAOBMMEACE | |
| SCHEMBL13996976 | 0.83 | TRPA1 (0.39) | TRPA1HPGDANPEP | |
| SCHEMBL13996985 | 0.83 | TRPA1 (0.39) | TRPA1HPGDANPEP | |
| SCHEMBL28916127 | 0.81 | TRPA1 (0.57) | TRPA1ANPEPMAOAMME | |
| SCHEMBL14003410 | 0.81 | TRPA1 (0.58) | TRPA1MAOAMAOBMMEACE | |
| SCHEMBL28915633 | 0.81 | TRPA1 (0.57) | TRPA1ANPEPMAOAMME | |
| SCHEMBL14402631 | 0.78 | TRPA1 (0.55) | TRPA1HPGDMAOAMAOBCPA1 | |
| SCHEMBL3932320 | 0.76 | TRPA1 (0.68) | TRPA1HPGDMAOAMAOBHTT | |
| SCHEMBL8522755 | 0.76 | TRPA1 (0.68) | TRPA1HPGDMAOAMAOBHTT | |
| SCHEMBL9170494 | 0.75 | TRPA1 (0.59) | TRPA1HPGDMAOAMAOBAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459460-B2 | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-02 | — | — | US | disclosed |