Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996985 | 1.00 | TRPA1 (0.39) | TRPA1HPGDANPEPHCRTR2ACACB | |
| SCHEMBL17736164 | 0.86 | IDO1 (0.42) | TRPA1HCRTR2ACACBIDO1TAAR1 | |
| SCHEMBL13996975 | 0.83 | TRPA1 (0.59) | TRPA1HPGDANPEP | |
| SCHEMBL28915633 | 0.82 | TRPA1 (0.57) | TRPA1ANPEPTAAR1SLC6A2 | |
| SCHEMBL28916127 | 0.82 | TRPA1 (0.57) | TRPA1ANPEPTAAR1SLC6A2 | |
| SCHEMBL345256 | 0.80 | TRPA1 (0.39) | TRPA1HCRTR2ACACBIDO1TAAR1 | |
| SCHEMBL15726082 | 0.80 | PPARG (0.41) | TRPA1HCRTR2ACACBIDO1 | |
| SCHEMBL19038363 | 0.76 | APP (0.37) | TRPA1HCRTR2ACACBIDO1 | |
| SCHEMBL12197642 | 0.75 | TRPA1 (0.44) | TRPA1HPGDHCRTR2ACACBIDO1 | |
| SCHEMBL10206049 | 0.75 | TRPA1 (0.44) | TRPA1HPGDHCRTR2ACACBIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459460-B2 | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-02 | — | — | US | disclosed |
| US-7459460-B2 | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-02 | — | — | US | disclosed |