SCHEMBL13997

SCHEMBL13997

Cc1nc2ccc(Br)cc2cc1C=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSMB5 P28074 1/20 0.47
ERN1 O75460 2/20 0.44
CASP3 P42574 2/20 0.44
ALDH1A1 P00352 4/20 0.43
BACE1 P56817 1/20 0.43
HTT P42858 1/20 0.43
CYP2A6 P11509 3/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2D6 P10635 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP3A4 P08684 1/20 0.42
RXFP1 Q9HBX9 2/20 0.41
CYP2C9 P11712 1/20 0.41
PRNP P04156 1/20 0.40
PPARG P37231 1/20 0.40
NR2E3 Q9Y5X4 1/20 0.40
NCOR2 Q9Y618 1/20 0.40
KDM4E B2RXH2 1/20 0.38
GAA P10253 1/20 0.38
PABPC1 P11940 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8672 0.80 CYP1A2 (0.57) ERN1ALDH1A1BACE1HTTCYP2A6
SCHEMBL790844 0.80 BACE1 (0.50) ERN1ALDH1A1BACE1HTTCYP2A6
SCHEMBL19330294 0.80 ALDH1A1 (0.47) ERN1ALDH1A1BACE1CYP2A6CYP1A2
SCHEMBL28980933 0.78 TDP1 (0.52) ERN1ALDH1A1HTTCYP1A2CYP2D6
SCHEMBL30081463 0.77 ALDH1A1 (0.58) ERN1ALDH1A1HTTCYP1A2CYP2C19
SCHEMBL715554 0.77 ALDH1A1 (0.58) ERN1ALDH1A1HTTCYP1A2CYP2C19
SCHEMBL8354251 0.76 GRM1 (0.50) PSMB5CASP3ALDH1A1BACE1HTT
SCHEMBL11096 0.76 CDK2 (0.40) PSMB5ERN1ALDH1A1BACE1CYP2A6
SCHEMBL2852989 0.76 PSMB5 (0.48) PSMB5CASP3ALDH1A1BACE1HTT
SCHEMBL11584110 0.76 ALDH1A1 (0.58) PSMB5CASP3ALDH1A1BACE1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011063233-A1 AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE AMGEN INC. (US) 2011-05-26 WO disclosed