Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14012127 | 0.89 | GSK3B (0.49) | GSK3BMAPK1HTTCHEK1PLAT | |
| SCHEMBL13998541 | 0.88 | GSK3B (0.71) | GSK3BMAPK1HTTCHEK1 | |
| SCHEMBL13146410 | 0.83 | GSK3B (0.79) | GSK3BCHEK1 | |
| SCHEMBL13998535 | 0.77 | GSK3B (0.70) | GSK3BMAPK1HTTCHEK1 | |
| SCHEMBL13998492 | 0.77 | GSK3B (0.64) | GSK3BCHEK1PLATROCK1MAPKAPK2 | |
| SCHEMBL13998548 | 0.77 | GSK3B (0.73) | GSK3BCHEK1 | |
| SCHEMBL13146324 | 0.75 | GSK3B (0.77) | GSK3BCHEK1 | |
| SCHEMBL14492492 | 0.75 | GSK3B (0.59) | GSK3BMAPK1HTTMAPKAPK2 | |
| SCHEMBL13305175 | 0.74 | GSK3B (0.48) | GSK3BCHEK1 | |
| SCHEMBL13304869 | 0.73 | GSK3B (0.77) | GSK3BCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470695-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-30 | — | — | US | disclosed |