Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11617183 | 0.82 | USP2 (0.64) | USP2KDM4EL3MBTL1POLBMEN1 | |
| SCHEMBL14003353 | 0.81 | USP2 (0.65) | USP2KDM4EL3MBTL1POLBMEN1 | |
| SCHEMBL4855453 | 0.81 | USP2 (0.65) | USP2KDM4EL3MBTL1POLBMEN1 | |
| SCHEMBL4857927 | 0.80 | USP2 (0.88) | USP2KDM4EL3MBTL1POLBMEN1 | |
| SCHEMBL14003589 | 0.78 | MAOA (0.41) | KDM4ELMNARAB9A | |
| SCHEMBL11663287 | 0.76 | USP2 (0.81) | USP2KDM4EL3MBTL1POLBMEN1 | |
| SCHEMBL4863640 | 0.76 | USP2 (0.62) | USP2KDM4EL3MBTL1POLBMEN1 | |
| Chlordimorine SCHEMBL2107476 | 0.75 | USP2 (0.57) | USP2KDM4EMEN1KMT2AALDH1A1 | |
| Chlordimorine SCHEMBL31122995 | 0.75 | USP2 (0.57) | USP2KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL11617799 | 0.72 | ALDH1A1 (0.63) | KDM4EL3MBTL1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452873-B2 | Inhibitors of GSK-3 and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-18 | — | — | US | disclosed |