SCHEMBL14004108

SCHEMBL14004108

Cc1ccc(C2C(=O)c3cccc4c(N)ccc(c34)C2=O)c(C)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 11/20 0.54
MEN1 O00255 10/20 0.54
USP2 O75604 9/20 0.54
KEAP1 Q14145 7/20 0.54
NFE2L2 Q16236 7/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
ATM Q13315 2/20 0.50
MAPT P10636 7/20 0.49
RECQL P46063 4/20 0.49
RGS12 O14924 3/20 0.49
THRB P10828 2/20 0.49
NPSR1 Q6W5P4 2/20 0.49
BRCA1 P38398 2/20 0.49
CYP1A2 P05177 1/20 0.49
POLB P06746 1/20 0.49
CYP3A4 P08684 1/20 0.49
PARP1 P09874 1/20 0.49
CYP2C9 P11712 1/20 0.49
APEX1 P27695 1/20 0.49
CASP1 P29466 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29353603 0.81 KMT2A (0.56) KMT2AMEN1MAPTNPSR1BRCA1
SCHEMBL29385571 0.77 KMT2A (0.68) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL2474686 0.77 KMT2A (0.68) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL22236929 0.73 KMT2A (0.59) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL11875196 0.71 KMT2A (0.56) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL12874092 0.70 KEAP1 (0.69) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL17576260 0.70 USP2 (0.55) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL16449728 0.69 KMT2A (0.82) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL30516566 0.68 USP2 (0.65) KMT2AMEN1USP2KEAP1NFE2L2
SCHEMBL29556131 0.68 USP2 (0.65) KMT2AMEN1USP2KEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7455916-B2 Organic electroluminescent element FUJI XEROX CO., LTD. (JP) 2008-11-25 US disclosed
US-7455916-B2 Organic electroluminescent element FUJI XEROX CO., LTD. (JP) 2008-11-25 US disclosed