SCHEMBL16449728

SCHEMBL16449728

Cc1cc(C)cc(N2C(=O)c3cccc4c(N)ccc(c34)C2=O)c1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 12/20 0.82
USP2 O75604 11/20 0.82
MEN1 O00255 11/20 0.82
KEAP1 Q14145 8/20 0.82
NFE2L2 Q16236 8/20 0.82
L3MBTL1 Q9Y468 1/20 0.82
MAPT P10636 8/20 0.69
ALDH1A1 P00352 6/20 0.69
HTT P42858 5/20 0.69
KDM4E B2RXH2 4/20 0.69
SMN1; SMN2 Q16637 2/20 0.69
ATM Q13315 2/20 0.61
CYP1B1 Q16678 1/20 0.57
RECQL P46063 4/20 0.56
RGS12 O14924 3/20 0.56
LMNA P02545 2/20 0.56
RAB9A P51151 3/20 0.53
TLR9 Q9NR96 1/20 0.51
CASP1 P29466 3/20 0.49
CASP7 P55210 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2482279 0.82 USP2 (1.00) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL29353566 0.82 USP2 (1.00) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL29385571 0.80 KMT2A (0.68) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL2474686 0.80 KMT2A (0.68) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL4101226 0.79 ALDH1A1 (0.73) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL2477451 0.78 KMT2A (0.76) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL7650466 0.78 KMT2A (0.70) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL9006270 0.77 KMT2A (1.00) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL1078941 0.77 MEN1 (0.49) KMT2AUSP2MEN1KEAP1NFE2L2
SCHEMBL29354879 0.77 MEN1 (0.49) KMT2AUSP2MEN1KEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2832838-B1 LUBRICATING OIL COMPOSITION FOR REFRIGERATING MACHINES IDEMITSU KOSAN CO (JP) 2020-07-01 EP disclosed
US-9828567-B2 Lubricating oil composition for refrigerating machines IDEMITSU KOSAN CO., LTD. (JP) 2017-11-28 US disclosed
US-9828567-B2 Lubricating oil composition for refrigerating machines IDEMITSU KOSAN CO., LTD. (JP) 2017-11-28 US disclosed
US-20170166832-A1 LUBRICATING OIL COMPOSITION FOR REFRIGERATING MACHINES IDEMITSU KOSAN CO., LTD. (JP) 2017-06-15 US disclosed
US-9617497-B2 Lubricating oil composition for refrigerating machines IDEMITSU KOSAN CO., LTD. (JP) 2017-04-11 US disclosed
US-9617497-B2 Lubricating oil composition for refrigerating machines IDEMITSU KOSAN CO., LTD. (JP) 2017-04-11 US disclosed
US-20150045265-A1 LUBRICATING OIL COMPOSITION FOR REFRIGERATING MACHINES IDEMITSU KOSAN, CO. LTD. (JP) 2015-02-12 US disclosed