SCHEMBL14004528

SCHEMBL14004528

C=CS(=O)(=O)CCNc1nc(NCCCOC)c(C#N)c(C)c1/N=N/c1ccc(/N=N/c2ccc(S(=O)(=O)O)cc2)c2ccccc12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.34
▸ POLB P06746 3/20 0.34
▸ MAPK8 P45983 2/20 0.33
▸ MAPK9 P45984 2/20 0.33
▸ MAPK10 P53779 2/20 0.33
▸ KMT2A Q03164 7/20 0.33
▸ GLO1 Q04760 1/20 0.33
▸ MEN1 O00255 5/20 0.33
▸ ALDH1A1 P00352 4/20 0.33
▸ MAPT P10636 2/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ RPS6KA3 P51812 1/20 0.33
▸ PKM P14618 1/20 0.32
▸ THRB P10828 1/20 0.31
▸ TDP1 Q9NUW8 1/20 0.31
▸ SENP3 Q9H4L4 2/20 0.30
▸ SENP2 Q9HC62 2/20 0.30
▸ SENP1 Q9P0U3 2/20 0.30
▸ SUMO2 P61956 1/20 0.30
▸ SUMO1 P63165 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14004526 1.00 KDM4E (0.34) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004520 0.95 MAPK8 (0.33) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004527 0.95 MAPK8 (0.33) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004513 0.92 GLO1 (0.34) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004518 0.92 GLO1 (0.34) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004355 0.91 CD40 (0.38) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004349 0.91 CD40 (0.38) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004374 0.91 CTRB1 (0.35) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004359 0.91 CTRB1 (0.35) KDM4EPOLBMAPK8MAPK9MAPK10
SCHEMBL14004442 0.88 MAPK8 (0.34) KDM4EPOLBMAPK8MAPK9MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080289124-A1 Reactive Azo Dyes, Methods for the Production Thereof and Their Use DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2008-11-27 — — US disclosed
US-20080289124-A1 Reactive Azo Dyes, Methods for the Production Thereof and Their Use DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2008-11-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080289124-A1 Reactive Azo Dyes, Methods for the Production Thereof and Their Use IK, CYP1A1, ALKBH1 KDM4E 390/4885POLB 3794/4885MAPK8 3121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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