Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.38 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | RRM1 | P23921 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14004683 | 0.97 | KISS1R (0.39) | SIRT6SIRT1CACNA1BKISS1RFOLH1 | |
| SCHEMBL14004818 | 0.97 | CACNA1B (0.39) | SIRT6SIRT1CACNA1BKISS1RDPP7 | |
| SCHEMBL14004821 | 0.97 | CACNA1B (0.39) | SIRT6SIRT1CACNA1BKISS1RDPP7 | |
| SCHEMBL14004784 | 0.94 | CACNA1B (0.38) | SIRT6SIRT1CACNA1BKISS1RDPP7 | |
| SCHEMBL14002547 | 0.94 | KISS1R (0.41) | SIRT6SIRT1CACNA1BKISS1R | |
| SCHEMBL14004779 | 0.93 | CACNA1B (0.37) | SIRT6SIRT1CACNA1BKISS1RDPP7 | |
| SCHEMBL14004811 | 0.92 | CACNA1B (0.49) | SIRT6SIRT1CACNA1BKISS1RMMP8 | |
| SCHEMBL14004837 | 0.92 | DPP7 (0.48) | SIRT6SIRT1CACNA1BDPP7TLR2 | |
| SCHEMBL14004788 | 0.90 | KISS1R (0.33) | SIRT6SIRT1CACNA1BKISS1R | |
| SCHEMBL14004819 | 0.90 | CASP2 (0.33) | SIRT6SIRT1CACNA1BKISS1RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | AICURIS GMBH & CO. KG (DE) | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275018-A1 | ANTIBACTERIAL AMIDE-MACROCYCLES V | ARG1, HRH3, H1-0 | SIRT6 126/4885SIRT1 276/4885CACNA1B 3579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.