Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005489 | 0.84 | CYP19A1 (0.41) | SYKABCG2KDREGFRERBB2 | |
| SCHEMBL14030129 | 0.81 | SLC2A1 (0.49) | SYKABCG2TP53FLT1FLT4 | |
| SCHEMBL1981048 | 0.77 | ABCG2 (0.51) | SYKABCG2TP53FLT1FLT4 | |
| SCHEMBL19077878 | 0.77 | GRM5 (0.63) | VNN1 | |
| SCHEMBL953597 | 0.76 | ALDH1A1 (0.56) | SYKABCG2FLT1FLT4KDR | |
| SCHEMBL10567345 | 0.72 | ABCG2 (0.57) | SYKABCG2FLT1FLT4KDR | |
| SCHEMBL6156438 | 0.71 | ALDH1A1 (0.61) | ABCG2TP53FLT1FLT4KDR | |
| SCHEMBL12026637 | 0.71 | CYP19A1 (0.40) | — | |
| SCHEMBL21439863 | 0.71 | NPSR1 (0.60) | ABCG2EGFRSLC2A1 | |
| SCHEMBL30619678 | 0.71 | NPSR1 (0.60) | ABCG2EGFRSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | SYK 478/4885ABCG2 2641/4885TP53 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.