Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005500 | 0.86 | TAS2R14 (0.58) | TAS2R14JAK2JAK1TYK2MAPK8 | |
| SCHEMBL14005497 | 0.80 | TAS2R14 (0.51) | TAS2R14SIRT2SIRT1SIRT3 | |
| SCHEMBL14005491 | 0.79 | MAPT (0.50) | TAS2R14SIRT2SIRT1SIRT3MAPK10 | |
| SCHEMBL14030188 | 0.79 | SIRT1 (0.54) | TAS2R14SIRT2SIRT1SIRT3 | |
| SCHEMBL17766595 | 0.77 | SIRT2 (0.56) | SIRT2SIRT1MAPK8MAPK10 | |
| SCHEMBL14005533 | 0.77 | SIRT2 (0.49) | SIRT2SIRT1SIRT3MAPK8 | |
| SCHEMBL14005502 | 0.76 | SIRT2 (0.52) | SIRT2SIRT1SIRT3TYK2 | |
| SCHEMBL14005531 | 0.76 | TAS2R14 (0.49) | TAS2R14SIRT2SIRT1SIRT3MAPK10 | |
| SCHEMBL14005512 | 0.76 | TAS2R14 (0.46) | TAS2R14SIRT2SIRT1SIRT3 | |
| SCHEMBL14005539 | 0.76 | TAS2R14 (0.43) | TAS2R14SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | TAS2R14 4288/4885SIRT2 1154/4885SIRT1 933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.