Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 3/20 | 0.42 |
| ▸ | KLK1 | P06870 | 3/20 | 0.42 |
| ▸ | KLK6 | Q92876 | 3/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | BPTF | Q12830 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | F9 | P00740 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14005506 | 0.87 | BPTF (0.43) | PLGKLK1KLK6KLKB1BPTF | |
| SCHEMBL14005509 | 0.85 | XDH (0.43) | XDHSLC22A12BRAFFLT1KDR | |
| SCHEMBL14005520 | 0.82 | KDR (0.45) | XDHSLC22A12HRH3FLT1KDR | |
| SCHEMBL14005522 | 0.79 | XDH (0.42) | XDHSLC22A12KIF11TDO2BRAF | |
| SCHEMBL14005526 | 0.79 | SLC22A12 (0.45) | XDHSLC22A12KIF11HRH3BRAF | |
| SCHEMBL14030068 | 0.78 | XDH (0.45) | PLGKLK1KLK6XDHSLC22A12 | |
| SCHEMBL14005485 | 0.77 | RAB9A (0.53) | XDHSLC22A12KCNH2SCN5ASCN9A | |
| SCHEMBL14005533 | 0.77 | SIRT2 (0.49) | XDHSLC22A12KDR | |
| SCHEMBL14068603 | 0.76 | KCNH2 (0.37) | PLGKLK1KLK6XDHSLC22A12 | |
| SCHEMBL14005511 | 0.75 | IKBKB (0.49) | XDHSLC22A12KIF11HRH3FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | PLG 2813/4885KLK1 1313/4885KLK6 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.