SCHEMBL140100

SCHEMBL140100

O=[N+]([O-])c1ccc(S(=O)(=O)Cl)c2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.53
CTSB P07858 4/20 0.53
KMT2A Q03164 4/20 0.47
ALDH1A1 P00352 4/20 0.47
MEN1 O00255 2/20 0.47
AR P10275 1/20 0.45
HPRT1 P00492 1/20 0.45
POLB P06746 1/20 0.44
ATM Q13315 1/20 0.44
KIF18A Q8NI77 1/20 0.43
NCOA1 Q15788 1/20 0.41
NCOA3 Q9Y6Q9 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
MMP1 P03956 1/20 0.41
MMP2 P08253 1/20 0.41
MMP9 P14780 1/20 0.41
MMP8 P22894 1/20 0.41
MMP13 P45452 1/20 0.41
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9798204 0.89 TDP1 (0.64) TDP1CTSBKMT2AALDH1A1MEN1
SCHEMBL9680529 0.82 CTSB (0.58) TDP1CTSBKMT2AALDH1A1MEN1
SCHEMBL31603825 0.82 TDP1 (0.53) TDP1CTSBKMT2AALDH1A1MEN1
SCHEMBL7788656 0.80 TDP1 (0.80) TDP1CTSBKMT2AALDH1A1MEN1
SCHEMBL9165551 0.80 ALDH1A1 (0.48) TDP1KMT2AALDH1A1MEN1POLB
SCHEMBL31603818 0.79 CTSB (0.50) TDP1CTSBKMT2AALDH1A1MEN1
SCHEMBL31603819 0.79 CTSB (0.50) TDP1CTSBKMT2AALDH1A1MEN1
SCHEMBL31025944 0.78 CTSB (0.49) TDP1CTSBKMT2AALDH1A1MEN1
SCHEMBL19682408 0.78 MAPT (0.60) TDP1CTSBKMT2AALDH1A1MEN1
SCHEMBL17278 0.77 KMT2A (0.70) TDP1KMT2AALDH1A1MEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10889849-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2021-01-12 US disclosed
US-20180030503-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2018-02-01 US disclosed
US-20180030503-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2018-02-01 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
EP-2611929-B1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORP (US) 2016-01-13 EP disclosed
EP-2611929-B1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORP (US) 2016-01-13 EP disclosed
EP-2611929-A1 OXIDIZED GLUTATHIONE ASSAY Promega Corporation (US) 2013-07-10 EP disclosed
WO-2012030960-A1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORPORATION (US) 2012-03-08 WO disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed