Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12150468 | 0.93 | LMNA (0.38) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 | |
| SCHEMBL12300344 | 0.85 | LMNA (0.45) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 | |
| SCHEMBL14071885 | 0.85 | CA1 (0.36) | TSHRCA1CA2CA9P2RX3 | |
| SCHEMBL12746699 | 0.82 | LMNA (0.44) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 | |
| SCHEMBL12300346 | 0.81 | LMNA (0.43) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 | |
| SCHEMBL12300734 | 0.81 | LMNA (0.48) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 | |
| SCHEMBL6912924 | 0.80 | LMNA (0.57) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 | |
| SCHEMBL12150445 | 0.80 | LMNA (0.43) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 | |
| SCHEMBL12154681 | 0.80 | LMNA (0.43) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 | |
| SCHEMBL12300349 | 0.79 | LMNA (0.47) | LMNASMN1; SMN2TSHRADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7429565-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-09-30 | — | — | US | disclosed |