Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202424 | 0.96 | DRD2 (0.55) | DRD2ASIC3HTR2CKDM4AKDM4B | |
| SCHEMBL1401419 | 0.80 | DRD2 (0.60) | DRD2HTR2CKDM4AKDM4BKDM5C | |
| Hydrochloric Acid SCHEMBL1401480 | 0.79 | DRD2 (0.58) | DRD2HTR2CKDM4AKDM4BKDM5C | |
| SCHEMBL9422688 | 0.78 | DRD2 (0.63) | DRD2HTR2CKDM4AKDM4BKDM5C | |
| SCHEMBL9311321 | 0.78 | DRD2 (0.66) | DRD2HTR2CKDM4AKDM4BKDM5C | |
| Hydrochloric Acid SCHEMBL9305904 | 0.77 | DRD2 (0.62) | DRD2HTR2CKDM4AKDM4BKDM5C | |
| SCHEMBL4587723 | 0.74 | DRD2 (0.57) | DRD2HTR2CKDM4AKDM4BKDM5C | |
| SCHEMBL4589239 | 0.74 | DRD2 (0.57) | DRD2HTR2CKDM4AKDM4BKDM5C | |
| SCHEMBL1401365 | 0.73 | DRD2 (0.56) | DRD2HTR2CKDM4AKDM4BKDM5C | |
| SCHEMBL1401478 | 0.73 | DRD2 (0.56) | DRD2HTR2CKDM4AKDM4BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326720-B2 | Phenyl- and pyridylpiperidines with TNF activity | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | claimed |
| EP-1383761-B1 | Phenyl- and pyridyl-piperidines with tnf activity | SANOFI AVENTIS (FR) | 2011-03-02 | — | — | EP | disclosed |
| US-7326720-B2 | Phenyl- and pyridylpiperidines with TNF activity | SANOFI-AVENTIS (FR) | 2008-02-05 | — | — | US | disclosed |
| US-20040127517-A1 | Phenyl-and pyridyl-piperidines with tnf activity | SANOFI-AVENTIS (FR) | 2004-07-01 | — | — | US | disclosed |
| EP-1383761-A1 | PHENYL- AND PYRIDYL-PIPERIDINES WITH TNF ACTIVITY | Sanofi-Aventis (FR) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002085887-A1 | PHENYL- AND PYRIDYL-PIPERIDINES WITH TNF ACTIVITY | SANOFI-SYNTHELABO (FR) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127517-A1 | Phenyl-and pyridyl-piperidines with tnf activity | TNF, TNFRSF1A, NGFR | DRD2 139/4885ASIC3 2342/4885HTR2C 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.