Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14013300 | 0.77 | RIPK1 (0.46) | RIPK1SSTR4KDM4EHPGD | |
| SCHEMBL29912684 | 0.72 | RIPK1 (0.68) | RIPK1 | |
| SCHEMBL1344891 | 0.72 | CA1 (0.38) | CTSSCTSKCA1CA2CA7 | |
| SCHEMBL1343095 | 0.72 | CA1 (0.38) | CTSSCTSKCA1CA2CA7 | |
| SCHEMBL17882288 | 0.72 | RIPK1 (0.68) | RIPK1 | |
| SCHEMBL6684667 | 0.69 | CTSS (0.43) | CTSSCTSKCA2CA7GAA | |
| SCHEMBL5230355 | 0.69 | ATM (0.40) | RIPK1TRPA1AAK1CTSSCTSK | |
| SCHEMBL5007460 | 0.68 | PPARA (0.55) | RIPK1CTSSCTSK | |
| SCHEMBL5007458 | 0.68 | PPARA (0.55) | RIPK1CTSSCTSK | |
| SCHEMBL14762235 | 0.67 | SSTR4 (0.52) | RIPK1SSTR4KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |