Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024154 | 0.83 | HTR7 (0.51) | BRD4ALDH1A1KDM4EHSD17B10CYP2A6 | |
| SCHEMBL1582995 | 0.79 | HTR7 (0.46) | BRD4ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8781944 | 0.79 | KMT2A (0.40) | ALDH1A1MAOBNPC1RAB9AMEN1 | |
| SCHEMBL9024407 | 0.71 | HTR2A (0.49) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9445146 | 0.71 | HTR2A (0.50) | BRD4ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9024716 | 0.69 | HTR7 (0.53) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL4845045 | 0.68 | NPC1 (0.36) | ESR1ESR2ALDH1A1TSHRHPGD | |
| SCHEMBL8789344 | 0.66 | NPC1 (0.44) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL15328766 | 0.65 | BRD4 (1.00) | BRD4 | |
| SCHEMBL9024849 | 0.64 | SMN1; SMN2 (0.42) | BRD4ALDH1A1TSHRHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1484325-B1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE & TECH AGENCY (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-7453001-B2 | Such as, ethyl 3-(2-hydroxyphenyl)-6-methyl4-oxo4,5,6,7-tetrahydrobenzo[d]isoxazole-5-carboxylate; intermediates | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-11-18 | — | — | US | disclosed |
| US-7453001-B2 | Such as, ethyl 3-(2-hydroxyphenyl)-6-methyl4-oxo4,5,6,7-tetrahydrobenzo[d]isoxazole-5-carboxylate; intermediates | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-11-18 | — | — | US | disclosed |
| US-7342036-B2 | Isoxazole derivatives and process for producing the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-11 | — | — | US | disclosed |
| US-7342036-B2 | Isoxazole derivatives and process for producing the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-11 | — | — | US | disclosed |
| US-20080058530-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-06 | — | — | US | disclosed |
| US-20080058530-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058530-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | CYP1A1, CYP1A2, CYP2E1 | BRD4 1391/4885ESR1 2321/4885ESR2 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.