Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131565 | 0.96 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1TSHRBRD4HTT | |
| SCHEMBL13145564 | 0.88 | BRD4 (0.41) | SMN1; SMN2BRD4HTR2AHTR1ADRD2 | |
| SCHEMBL21614780 | 0.76 | BRD4 (0.41) | BRD4CYP1A2CYP2C9 | |
| SCHEMBL23080469 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TSHRHTTCYP1A2 | |
| SCHEMBL5725151 | 0.72 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1BRD4CYP1A2CYP2C9 | |
| SCHEMBL21987985 | 0.69 | BRD4 (0.54) | BRD4HTR2AHTR1ADRD2 | |
| SCHEMBL1582995 | 0.68 | HTR7 (0.46) | SMN1; SMN2ALDH1A1BRD4HPGDHSD17B10 | |
| SCHEMBL8866040 | 0.68 | ALDH1A1 (0.34) | SMN1; SMN2ALDH1A1TSHRBRD4NR3C1 | |
| SCHEMBL3139058 | 0.67 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1TSHRBRD4HTR2A | |
| SCHEMBL9445146 | 0.66 | HTR2A (0.50) | SMN1; SMN2ALDH1A1BRD4HTR2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474012-B1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5256672-A | Antipsychotic, analgesic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-26 | — | — | US | disclosed |
| US-5180834-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-19 | — | — | US | disclosed |
| US-5114936-A | Antipsychotic and analgesic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0474012-A1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-03-11 | — | — | EP | disclosed |