Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | AOC1 | P19801 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917582 | 0.85 | MAOA (0.39) | RAB9ATP53HPGDALDH1A1MAPT | |
| SCHEMBL14014136 | 0.68 | BRD4 (0.48) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL13837599 | 0.63 | HSD17B10 (0.54) | NPC1SMN1; SMN2HPGDALDH1A1HSP90AB1 | |
| SCHEMBL5820169 | 0.62 | EDNRB (0.45) | ALDH1A1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL27927955 | 0.61 | HSD17B10 (0.55) | ALDH1A1MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL5952009 | 0.60 | ACHE (0.62) | SMN1; SMN2HPGDALDH1A1MAPTACHE | |
| SCHEMBL14261867 | 0.59 | ESR1 (0.72) | NPC1RAB9ASMN1; SMN2HPGDNFKB1 | |
| SCHEMBL5730461 | 0.58 | ESR1 (0.53) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL5952103 | 0.58 | ACHE (0.59) | ALDH1A1MAPTMEN1KMT2AACHE | |
| SCHEMBL13115609 | 0.57 | ACHE (0.68) | SMN1; SMN2HPGDALDH1A1MAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1484325-B1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE & TECH AGENCY (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-7453001-B2 | Such as, ethyl 3-(2-hydroxyphenyl)-6-methyl4-oxo4,5,6,7-tetrahydrobenzo[d]isoxazole-5-carboxylate; intermediates | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-11-18 | — | — | US | disclosed |
| US-7342036-B2 | Isoxazole derivatives and process for producing the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-11 | — | — | US | disclosed |
| EP-1484325-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Japan Science and Technology Agency (JP) | 2004-12-08 | — | — | EP | disclosed |