Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 14/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | RPA1 | P27694 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014207 | 0.93 | KDM4E (0.60) | MARS1KDM4EALDH1A1TTRRPA1 | |
| SCHEMBL14014214 | 0.91 | KDM4E (0.59) | MARS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14014212 | 0.90 | ALDH1A1 (0.66) | MARS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14014202 | 0.90 | ALDH1A1 (0.69) | MARS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14014203 | 0.89 | KDM4E (0.55) | MARS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14014187 | 0.88 | KDM4E (0.68) | MARS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14014104 | 0.88 | KDM4E (0.68) | MARS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14014232 | 0.87 | KDM4E (0.53) | MARS1KDM4EALDH1A1TTRRPA1 | |
| SCHEMBL14014210 | 0.86 | MARS1 (0.63) | MARS1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14014206 | 0.86 | KDM4E (0.59) | MARS1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |