Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MARS1 | P56192 | 15/20 | 0.55 |
| ▸ | RPA1 | P27694 | 2/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014212 | 0.94 | ALDH1A1 (0.66) | KDM4EALDH1A1MARS1 | |
| SCHEMBL14014202 | 0.94 | ALDH1A1 (0.69) | KDM4EALDH1A1MARS1SMN1; SMN2 | |
| SCHEMBL14014205 | 0.93 | MARS1 (0.55) | KDM4EALDH1A1MARS1RPA1TTR | |
| SCHEMBL14014232 | 0.91 | KDM4E (0.53) | KDM4EALDH1A1MARS1RPA1TTR | |
| SCHEMBL14014193 | 0.91 | KDM4E (0.60) | KDM4EALDH1A1MARS1RPA1TTR | |
| SCHEMBL14014210 | 0.90 | MARS1 (0.63) | KDM4EALDH1A1MARS1RPA1 | |
| SCHEMBL14014206 | 0.90 | KDM4E (0.59) | KDM4EALDH1A1MARS1TTRSMN1; SMN2 | |
| SCHEMBL14014211 | 0.90 | KDM4E (0.57) | KDM4EALDH1A1MARS1 | |
| SCHEMBL14014330 | 0.89 | ALDH1A1 (0.65) | KDM4EALDH1A1MARS1RPA1TTR | |
| SCHEMBL14014189 | 0.87 | KDM4E (0.77) | KDM4EALDH1A1RPA1TTRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |