Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 10/20 | 0.52 |
| ▸ | FABP4 | P15090 | 4/20 | 0.49 |
| ▸ | FABP3 | P05413 | 2/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | MARS1 | P56192 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014327 | 0.93 | KDM4E (0.61) | KDM4EALDH1A1PTGER1FABP4FABP3 | |
| SCHEMBL14014224 | 0.92 | KDM4E (0.55) | KDM4EALDH1A1PTGER1FABP4FABP3 | |
| SCHEMBL14014340 | 0.91 | KDM4E (0.53) | KDM4EALDH1A1PTGER1FABP4FABP3 | |
| SCHEMBL14014294 | 0.87 | PTGER1 (0.52) | KDM4EALDH1A1PTGER1TBXA2RMARS1 | |
| SCHEMBL14014226 | 0.86 | ALDH1A1 (0.63) | KDM4EALDH1A1MDM2TP53MCL1 | |
| SCHEMBL14014339 | 0.86 | ALDH1A1 (0.63) | KDM4EALDH1A1MDM2TP53MCL1 | |
| SCHEMBL14014334 | 0.86 | KDM4E (0.59) | KDM4EALDH1A1FABP4FABP3MDM2 | |
| SCHEMBL14014314 | 0.85 | KDM4E (0.53) | KDM4EALDH1A1PTGER1FABP4FABP3 | |
| SCHEMBL14014296 | 0.84 | MARS1 (0.54) | KDM4EALDH1A1MDM2MARS1MCL1 | |
| SCHEMBL14014330 | 0.82 | ALDH1A1 (0.65) | KDM4EALDH1A1TP53MARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |