Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 8/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014609 | 0.90 | HSD17B10 (0.44) | DHODHPLATHSD17B10KEAP1NFE2L2 | |
| SCHEMBL14014603 | 0.89 | HSD17B10 (0.46) | DHODHPLATHSD17B10PIM1FLT3 | |
| SCHEMBL14014941 | 0.86 | GCGR (0.45) | — | |
| SCHEMBL14014602 | 0.83 | ALOX5AP (0.40) | DHODHPLAT | |
| SCHEMBL14014545 | 0.81 | NR4A2 (0.48) | PLATHSD17B10PIM1 | |
| SCHEMBL14014880 | 0.81 | KEAP1 (0.46) | FLT3KEAP1NFE2L2 | |
| SCHEMBL14014541 | 0.81 | PLAT (0.43) | PLATPIM1PIM2FLT3DYRK1A | |
| SCHEMBL4708491 | 0.81 | HSD17B10 (0.47) | DHODHHSD17B10PIM1FLT3KEAP1 | |
| SCHEMBL14014598 | 0.80 | HSD17B10 (0.41) | PLATHSD17B10PIM1FLT3KEAP1 | |
| SCHEMBL14014913 | 0.80 | KDM4E (0.46) | PLATHSD17B10FLT3KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |