Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 9/20 | 0.45 |
| ▸ | CAMKK1 | Q8N5S9 | 8/20 | 0.45 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.41 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014888 | 0.98 | CAMKK2 (0.47) | KEAP1NFE2L2CAMKK2CAMKK1BRS3 | |
| SCHEMBL14014957 | 0.91 | AXL (0.41) | KEAP1NFE2L2CAMKK2CAMKK1AXL | |
| SCHEMBL4708838 | 0.90 | BRS3 (0.46) | KEAP1NFE2L2CAMKK2CAMKK1BRS3 | |
| SCHEMBL4710750 | 0.90 | KDM4E (0.52) | KEAP1NFE2L2CAMKK2CAMKK1BRS3 | |
| SCHEMBL6211737 | 0.90 | CAMKK2 (0.40) | KEAP1NFE2L2CAMKK2CAMKK1BRS3 | |
| SCHEMBL14014496 | 0.88 | KDM4E (0.56) | KEAP1NFE2L2CAMKK2CAMKK1AXL | |
| SCHEMBL14014911 | 0.88 | CAMKK1 (0.44) | KEAP1NFE2L2CAMKK2CAMKK1SGK1 | |
| SCHEMBL14014510 | 0.88 | MCL1 (0.43) | BRS3KMT2AKDM4E | |
| SCHEMBL14014967 | 0.87 | KEAP1 (0.39) | KEAP1NFE2L2CAMKK2CAMKK1NPC1 | |
| SCHEMBL14014928 | 0.87 | GABBR2 (0.42) | CAMKK2CAMKK1NPC1RAB9AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |