Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014608 | 0.90 | DHODH (0.44) | HSD17B10KEAP1NFE2L2PLATDHODH | |
| SCHEMBL14014545 | 0.89 | NR4A2 (0.48) | HSD17B10MCL1TNK2PLATBTK | |
| SCHEMBL14014913 | 0.88 | KDM4E (0.46) | HSD17B10KDM4EKEAP1NFE2L2CAMKK1 | |
| SCHEMBL14014603 | 0.86 | HSD17B10 (0.46) | HSD17B10KDM4EKEAP1NFE2L2CAMKK1 | |
| SCHEMBL14014924 | 0.83 | KDM4E (0.38) | HSD17B10KDM4EKEAP1NFE2L2CAMKK1 | |
| SCHEMBL14014928 | 0.83 | GABBR2 (0.42) | KDM4ECAMKK1CAMKK2PLATALDH1A1 | |
| SCHEMBL14014539 | 0.81 | PLAT (0.37) | TNK2PLATBTKTP53 | |
| SCHEMBL14014880 | 0.81 | KEAP1 (0.46) | KDM4EKEAP1NFE2L2CAMKK1CAMKK2 | |
| SCHEMBL4708491 | 0.80 | HSD17B10 (0.47) | HSD17B10KDM4EKEAP1NFE2L2CAMKK1 | |
| SCHEMBL14014888 | 0.79 | CAMKK2 (0.47) | KDM4EKEAP1NFE2L2CAMKK1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |