Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 5/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 3/20 | 0.33 |
| ▸ | GIPR | P48546 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014550 | 0.94 | TNK2 (0.41) | GABBR2GABBR1TNK2BTKPLAT | |
| SCHEMBL14014641 | 0.91 | GABBR2 (0.37) | GABBR2GABBR1PLATNPC1RAB9A | |
| SCHEMBL14541774 | 0.90 | NPC1 (0.33) | BTKNPC1RAB9AKMT2A | |
| SCHEMBL14014652 | 0.89 | LCK (0.39) | TNK2BTKNPC1RAB9AKMT2A | |
| SCHEMBL14014541 | 0.88 | PLAT (0.43) | TNK2BTKPLAT | |
| SCHEMBL14014558 | 0.87 | TNK2 (0.41) | TNK2ABL1BTKPLATSCN9A | |
| SCHEMBL14014616 | 0.86 | JAK1 (0.40) | GABBR2GABBR1GCGRPLAT | |
| SCHEMBL14014697 | 0.86 | NPC1 (0.32) | NPC1RAB9AKMT2A | |
| SCHEMBL14014671 | 0.85 | BTK (0.33) | BTKNPC1RAB9AKMT2ASCN9A | |
| SCHEMBL14542071 | 0.84 | ACVR1 (0.36) | NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |