Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 3/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.37 |
| ▸ | PLAT | P00750 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014558 | 0.92 | TNK2 (0.41) | PLATGPR119LTA4HAXLTYRO3 | |
| SCHEMBL14014643 | 0.91 | GABBR2 (0.39) | GABBR2GABBR1PLATNPC1RAB9A | |
| SCHEMBL14541774 | 0.90 | NPC1 (0.33) | NPC1RAB9AKMT2A | |
| SCHEMBL14014652 | 0.89 | LCK (0.39) | GPR119NPC1RAB9AKMT2A | |
| SCHEMBL14014550 | 0.87 | TNK2 (0.41) | GABBR2GABBR1PLATPIM1 | |
| SCHEMBL14014697 | 0.86 | NPC1 (0.32) | NPC1RAB9AKMT2A | |
| SCHEMBL14014539 | 0.85 | PLAT (0.37) | PLATLTA4HAXLTYRO3PIM1 | |
| SCHEMBL14014630 | 0.85 | GPR119 (0.34) | GABBR2GABBR1PLATGPR119AXL | |
| SCHEMBL14014671 | 0.85 | BTK (0.33) | NPC1RAB9AKMT2A | |
| SCHEMBL14014665 | 0.85 | ALOX5AP (0.33) | GABBR2GABBR1PLATGPR119AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |