Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014639 | 0.92 | TNK2 (0.38) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL14014671 | 0.90 | BTK (0.33) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL14014652 | 0.89 | LCK (0.39) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL14541774 | 0.88 | NPC1 (0.33) | NPC1RAB9AKMT2AMEN1DGAT1 | |
| SCHEMBL14014567 | 0.87 | LCK (0.35) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL14014700 | 0.87 | CHEK2 (0.33) | NPC1RAB9ARXFP1KMT2AMEN1 | |
| SCHEMBL14014565 | 0.86 | KMT2A (0.39) | NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL14014641 | 0.86 | GABBR2 (0.37) | NPC1RAB9AKMT2A | |
| SCHEMBL14014643 | 0.86 | GABBR2 (0.39) | NPC1RAB9AKMT2A | |
| SCHEMBL4709333 | 0.85 | TNK2 (0.38) | NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |