Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | GCGR | P47871 | 4/20 | 0.32 |
| ▸ | GIPR | P48546 | 3/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.30 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014584 | 0.92 | PLAT (0.36) | ALOX5APPLATS1PR1PDCD1CD274 | |
| SCHEMBL14014668 | 0.89 | S1PR1 (0.36) | S1PR1 | |
| SCHEMBL14014669 | 0.88 | S1PR1 (0.35) | SCN9APTGDR2ALOX5APS1PR1GRM2 | |
| SCHEMBL14014616 | 0.88 | JAK1 (0.40) | ALOX5APPLATGCGRGRM2JAK1 | |
| SCHEMBL14014628 | 0.84 | PDE2A (0.33) | ALOX5APS1PR1GRM2 | |
| SCHEMBL4710343 | 0.84 | CYP3A4 (0.39) | ALOX5APS1PR1 | |
| SCHEMBL14014686 | 0.84 | ALOX5AP (0.33) | ALOX5APGRM2 | |
| SCHEMBL14014665 | 0.82 | ALOX5AP (0.33) | ALOX5APPLATGABBR2GABBR1 | |
| SCHEMBL14014587 | 0.82 | PLAT (0.41) | ALOX5APPLATJAK1 | |
| SCHEMBL14014643 | 0.82 | GABBR2 (0.39) | SCN9ASCN10APLATGCGRGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |