Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | FYN | P06241 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | FLT1 | P17948 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | NEK2 | P51955 | 2/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.31 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014630 | 0.92 | GPR119 (0.34) | ALOX5APFFAR4GPR119PRMT5PLAT | |
| SCHEMBL14014669 | 0.87 | S1PR1 (0.35) | ALOX5APPRMT5JAK2JAK3 | |
| SCHEMBL4710343 | 0.86 | CYP3A4 (0.39) | ALOX5APFFAR4GPR119TYRO3AXL | |
| SCHEMBL14014641 | 0.85 | GABBR2 (0.37) | GPR119PLATTYRO3AXLGABBR2 | |
| SCHEMBL14014668 | 0.84 | S1PR1 (0.36) | PDGFRA | |
| SCHEMBL14014625 | 0.84 | GPR119 (0.37) | ALOX5APFFAR4GPR119PRMT5TYRO3 | |
| SCHEMBL14014662 | 0.82 | SCN1A (0.36) | ALOX5APPLATGABBR2GABBR1 | |
| SCHEMBL14014558 | 0.82 | TNK2 (0.41) | GPR119PLATABL1NTRK1LCK | |
| Tetrazole SCHEMBL4710754 | 0.82 | CYP3A4 (0.36) | ALOX5APGPR119TYRO3AXLPDGFRA | |
| SCHEMBL14014628 | 0.81 | PDE2A (0.33) | ALOX5APGPR119PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |