Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethanolamine SCHEMBL1834267 | 1.00 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Diethanolamine SCHEMBL8849809 | 0.97 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Diethanolamine SCHEMBL1833343 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Diethanolamine SCHEMBL1832822 | 0.90 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Bicarbonate SCHEMBL4329497 | 0.87 | SMN1; SMN2 (0.39) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Diethanolamine SCHEMBL30231435 | 0.87 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Diethanolamine SCHEMBL1837947 | 0.85 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Diethanolamine SCHEMBL11848123 | 0.84 | KDM4E (0.37) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Diethanolamine SCHEMBL9588654 | 0.84 | ACHE (0.44) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 | |
| Malonic Acid SCHEMBL5875293 | 0.84 | LDHA (0.56) | KDM4EALDH1A1SMN1; SMN2HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113698124-B | Alkali-free liquid accelerator and preparation method thereof | 中铁十一局集团桥梁有限公司 | 2022-06-24 | — | — | CN | claimed |
| CN-113698124-A | Alkali-free liquid accelerator and preparation method thereof | 中铁十一局集团桥梁有限公司 | 2021-11-26 | — | — | CN | claimed |
| US-7141532-B2 | Process for the preparation of a dry pesticidal composition containing a dicarboxylate component | MONSANTO TECHNOLOGY LLC (US) | 2006-11-28 | — | — | US | claimed |
| EP-1538910-A2 | PROCESS FOR THE PREPARATION OF A DRY PESTICIDAL COMPOSITION CONTAINING A DICARBOXYLATE COMPONENT | Monsanto Technology LLC (US) | 2005-06-15 | — | — | EP | claimed |
| US-20040077499-A1 | Process for the preparation of a dry pesticidal composition containing a dicarboxylate component | MONSANTO TECHNOLOGY LLC | 2004-04-22 | — | — | US | claimed |
| WO-2004019684-A2 | PROCESS FOR THE PREPARATION OF A DRY PESTICIDAL COMPOSITION CONTAINING A DICARBODYLATE COMPONENT | MONSANTO TECHNOLOGY LLC (US) | 2004-03-11 | — | — | WO | claimed |
| US-6034035-A | CONTAINING AN AMINE AND OXALIC ACID | KAO CORPORATION (JP) | 2000-03-07 | — | — | US | claimed |
| CN-113698124-B | Alkali-free liquid accelerator and preparation method thereof | 中铁十一局集团桥梁有限公司 | 2022-06-24 | — | — | CN | disclosed |
| CN-113698124-B | Alkali-free liquid accelerator and preparation method thereof | 中铁十一局集团桥梁有限公司 | 2022-06-24 | — | — | CN | disclosed |
| CN-113698124-A | Alkali-free liquid accelerator and preparation method thereof | 中铁十一局集团桥梁有限公司 | 2021-11-26 | — | — | CN | disclosed |
| CN-113698124-A | Alkali-free liquid accelerator and preparation method thereof | 中铁十一局集团桥梁有限公司 | 2021-11-26 | — | — | CN | disclosed |
| US-10736325-B2 | Surfactants and formulations | MONSANTO TECHNOLOGY LLC (US) | 2020-08-11 | — | — | US | disclosed |
| EP-3662027-A1 | COPPER INK | National Research Council of Canada (CA) | 2020-06-10 | — | — | EP | disclosed |
| EP-0777416-B1 | LIQUID COMPOSITION FOR STABILIZING BIPYRIDINIUM SERIES HERBICIDES | KAO CORP (JP) | 1999-10-27 | — | — | EP | disclosed |
| EP-0777418-B1 | LIQUID COMPOSITION FOR STABILIZING AMINO ACID SERIES HERBICIDES | KAO CORP (JP) | 1999-09-08 | — | — | EP | disclosed |
| US-5863863-A | IMPROVING THE STORAGE STABILITY, RESIST TO TEMPERATURE CHANGE THE AQUEOUS SOLUTION COMPRISING AT LEAST ONE TERTIARY AMINE COMPOUNDS AND AT LEAST ONE OXALIC ACID OR IT'S DERIVATIVES | KAO CORPORATION (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0777418-A1 | LIQUID COMPOSITION FOR STABILIZING AMINO ACID SERIES HERBICIDES | Kao Corporation (JP) | 1997-06-11 | — | — | EP | disclosed |
| EP-0777416-A1 | LIQUID COMPOSITION FOR STABILIZING BIPYRIDINIUM SERIES HERBICIDES | Kao Corporation (JP) | 1997-06-11 | — | — | EP | disclosed |
| WO-1997001276-A1 | LIQUID COMPOSITION FOR STABILIZING BIPYRIDINIUM SERIES HERBICIDES | KAO CORPORATION (JP) | 1997-01-16 | — | — | WO | disclosed |
| WO-1997001281-A1 | LIQUID COMPOSITION FOR STABILIZING AMINO ACID SERIES HERBICIDES | KAO CORPORATION (JP) | 1997-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10736325-B2 | Surfactants and formulations | PHOSPHO1, GNMT, DDT | KDM4E 651/4885ALDH1A1 3698/4885SMN1; SMN2 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.