Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.60 |
| ▸ | HTR3B | O95264 | 1/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.60 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3177266 | 1.00 | HTR3A (0.60) | HTR3AHTR3EHTR3BCHRM4CHRM5 | |
| SCHEMBL6888233 | 0.94 | HTR3A (0.69) | HTR3AHTR3EHTR3BCHRM4CHRM5 | |
| SCHEMBL6887110 | 0.94 | HTR3A (0.69) | HTR3AHTR3EHTR3BCHRM4CHRM5 | |
| SCHEMBL13529096 | 0.80 | HTR3E (0.46) | HTR3AHTR3EHTR3BCHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL10538915 | 0.79 | MEN1 (0.48) | HTR3AMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL11104244 | 0.77 | POLB (0.47) | HTR3AHTR3EHTR3BCHRM4CHRM5 | |
| SCHEMBL28306051 | 0.77 | IDO1 (0.50) | MEN1KMT2AALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL6892215 | 0.76 | CHRNA3 (0.71) | HTR3AHTR3EHTR3BCHRM4CHRM5 | |
| SCHEMBL6886540 | 0.76 | CHRNA3 (0.71) | HTR3AHTR3EHTR3BCHRM4CHRM5 | |
| SCHEMBL14191714 | 0.76 | CHEK2 (0.39) | HTR3AHTR3EHTR3BCHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439239-B2 | Tricyclic δ- opioid modulators | JANSSEN PHARMACEUTICA N.V. (BG) | 2008-10-21 | — | — | US | disclosed |
| US-7439239-B2 | Tricyclic δ- opioid modulators | JANSSEN PHARMACEUTICA N.V. (BG) | 2008-10-21 | — | — | US | disclosed |