Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.38 |
| ▸ | EGFR | P00533 | 7/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820537 | 0.86 | ERBB2 (0.43) | AAK1ERBB2EGFRMET | |
| SCHEMBL1219397 | 0.81 | AAK1 (0.61) | AAK1ERBB2EGFRMETCKS1B | |
| SCHEMBL14017710 | 0.79 | MET (0.54) | AAK1ERBB2EGFRMET | |
| SCHEMBL14017705 | 0.78 | MAOA (0.39) | AAK1MET | |
| SCHEMBL4817685 | 0.74 | CA14 (0.36) | AAK1DRD2CKS1BSKP1SKP2 | |
| SCHEMBL4820542 | 0.73 | ERBB2 (0.39) | AAK1ERBB2EGFRMET | |
| SCHEMBL14017672 | 0.71 | MET (0.55) | AAK1ERBB2EGFRMET | |
| SCHEMBL4813480 | 0.70 | ERBB2 (0.54) | AAK1ERBB2EGFRMET | |
| SCHEMBL25080814 | 0.70 | NAMPT (0.53) | NAMPTDRD2CKS1BSKP1SKP2 | |
| SCHEMBL1220105 | 0.68 | EPHA2 (0.42) | AAK1ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439246-B2 | Fused heterocyclic kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439246-B2 | Fused heterocyclic kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-21 | — | — | US | disclosed |
| US-7173031-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-06 | — | — | US | disclosed |