Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666371 | 0.89 | MAOB (0.41) | SMN1; SMN2RAB9AGFERFFAR1CD38 | |
| SCHEMBL30765134 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9AGFERFFAR1CD38 | |
| SCHEMBL1798143 | 0.77 | CSNK2A2 (0.47) | SMN1; SMN2MAPTLMNAPLAU | |
| SCHEMBL9071499 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2RAB9AGFERFFAR1KCNJ5 | |
| SCHEMBL6040690 | 0.75 | MAPK14 (0.44) | SMN1; SMN2RAB9AGFERNPC1MAPT | |
| SCHEMBL19329815 | 0.70 | MCL1 (0.49) | CD38MAPTLMNAMAOBEPHX2 | |
| SCHEMBL14191734 | 0.70 | CACNA1B (0.51) | RAB9ANPC1PARP10MAOBMEN1 | |
| SCHEMBL14018144 | 0.69 | MAOB (0.51) | FFAR1PARP10MAOB | |
| SCHEMBL8755190 | 0.69 | RAB9A (0.59) | SMN1; SMN2RAB9AGFERFFAR1MAPT | |
| SCHEMBL2518714 | 0.68 | RAB9A (0.54) | SMN1; SMN2RAB9AGFERFFAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987831-A1 | COMPOUNDS EFFECTING GLUCOKINASE | AstraZeneca AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1568367-B1 | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2007-04-18 | — | — | EP | disclosed |