Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31590539 | 0.80 | KDM4E (0.49) | MAPK1NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL28563324 | 0.76 | SMN1; SMN2 (0.47) | MAPK1NPC1RAB9APOLBCYP3A4 | |
| SCHEMBL8053528 | 0.75 | MAPK1 (0.62) | MAPK1NPC1RAB9APOLBALPL | |
| SCHEMBL14019194 | 0.75 | MAPK1 (0.54) | MAPK1NPC1RAB9APOLBLMNA | |
| SCHEMBL4033964 | 0.74 | SMN1; SMN2 (0.60) | MAPK1NPC1RAB9APOLBCYP2C9 | |
| SCHEMBL6350652 | 0.74 | HPGD (0.50) | MAPK1NPC1RAB9APOLBLMNA | |
| SCHEMBL19358351 | 0.73 | MAPK1 (0.61) | MAPK1NPC1RAB9APOLBALPL | |
| SCHEMBL5010442 | 0.73 | NPC1 (0.49) | MAPK1NPC1RAB9APOLBCYP2C19 | |
| SCHEMBL28568465 | 0.71 | RAB9A (0.46) | NPC1RAB9ACYP2C9CYP3A4CYP2C19 | |
| SCHEMBL3624738 | 0.71 | MAPK1 (0.67) | MAPK1NPC1RAB9APOLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432379-B2 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |