Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8762392 | 0.81 | LMNA (0.65) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL14907949 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9APARP1ALDH1A1 | |
| SCHEMBL8631029 | 0.80 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL20528632 | 0.79 | CA1 (0.62) | SMN1; SMN2RAB9AKDM4EALDH1A1GAA | |
| SCHEMBL37273 | 0.78 | ALDH1A1 (0.68) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL27860725 | 0.77 | HDAC1 (0.65) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL405785 | 0.77 | HDAC1 (0.69) | NPC1RAB9AHDAC1HDAC6PARP1 | |
| SCHEMBL30046370 | 0.77 | HDAC1 (0.69) | NPC1RAB9AHDAC1HDAC6PARP1 | |
| SCHEMBL19672737 | 0.76 | NPC1 (0.56) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 | |
| SCHEMBL27163388 | 0.75 | NPC1 (0.57) | SMN1; SMN2NPC1RAB9AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343503-B1 | HETEROARYL UREA NEUROPEPTIDE Y Y5 RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2008-11-12 | — | — | EP | disclosed |
| US-7309704-B2 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | SCHERING CORPORATION (US) | 2007-12-18 | — | — | US | disclosed |
| US-7309704-B2 | Heteroaryl urea neuropeptide Y Y5 receptor antagonists | SCHERING CORPORATION (US) | 2007-12-18 | — | — | US | disclosed |