SCHEMBL405785

SCHEMBL405785

NNC(=O)c1cccc(F)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.69
HDAC6 Q9UBN7 1/20 0.69
KDM4E B2RXH2 3/20 0.63
ALDH1A1 P00352 2/20 0.63
PARP1 P09874 1/20 0.62
CES2 O00748 2/20 0.61
CES1 P23141 2/20 0.61
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
KCNK3 O14649 2/20 0.57
L3MBTL1 Q9Y468 1/20 0.56
AOC2 O75106 1/20 0.54
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
HPGD P15428 1/20 0.54
CASP3 P42574 1/20 0.53
SENP7 Q9BQF6 1/20 0.53
SENP6 Q9GZR1 1/20 0.53
GRM5 P41594 1/20 0.53
KCNK9 Q9NPC2 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30046370 1.00 HDAC1 (0.69) HDAC1HDAC6KDM4EALDH1A1PARP1
SCHEMBL4238810 0.87 KMT2A (0.67) KDM4EALDH1A1MEN1KMT2AKCNK3
SCHEMBL77384 0.85 ALDH1A1 (0.76) HDAC6KDM4EALDH1A1MEN1KMT2A
SCHEMBL29200437 0.83 HDAC1 (0.50) HDAC1HDAC6KDM4EALDH1A1PARP1
SCHEMBL30986828 0.82 HDAC6 (1.00) HDAC1HDAC6KDM4EPARP1CES2
SCHEMBL28885353 0.82 HDAC6 (1.00) HDAC1HDAC6KDM4EPARP1CES2
SCHEMBL29379935 0.82 HDAC6 (1.00) HDAC1HDAC6KDM4EPARP1CES2
SCHEMBL1904111 0.81 ALDH1A1 (0.70) KDM4EALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL14907946 0.80 GAA (0.61) HDAC1HDAC6KDM4EALDH1A1PARP1
SCHEMBL4910885 0.80 HDAC1 (0.69) HDAC1HDAC6KDM4EALDH1A1PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 283 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119977832-A Benzoyl hydrazine antineoplastic compound and preparation method and application thereof 江苏海洋大学 2025-05-13 CN claimed
CN-119674192-A PVDF-based organic-inorganic composite polymer solid electrolyte and preparation method and application thereof 山东创鲁先进电池科技有限公司 2025-03-21 CN claimed
US-11398630-B2 Method of generating energy from a hydrazide containing anode fuel, and fuel cell IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2022-07-26 US claimed
US-20210005900-A1 METHOD OF GENERATING ENERGY FROM A HYDRAZIDE CONTAINING ANODE FUEL, AND FUEL CELL IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2021-01-07 US claimed
US-10040741-B2 Method for manufacturing high purity glycol based compound SAMSUNG DISPLAY CO., LTD. (KR) 2018-08-07 US claimed
US-20160297732-A1 METHOD FOR MANUFACTURING HIGH PURITY GLYCOL BASED COMPOUND SAMSUNG DISPLAY CO., LTD. (KR) 2016-10-13 US claimed
US-6337368-B1 WATER INSOLUBLE CARRIERS WITH P-NITROBENZOIC ACID, AROMATIC AMINES, AMIDES, SULFONAMIDES AND HYDRAZIDES KANEKA CORPORATION (JP) 2002-01-08 US claimed
US-12338243-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-06-24 US disclosed
CN-119977832-A Benzoyl hydrazine antineoplastic compound and preparation method and application thereof 江苏海洋大学 2025-05-13 CN disclosed
CN-119674192-A PVDF-based organic-inorganic composite polymer solid electrolyte and preparation method and application thereof 山东创鲁先进电池科技有限公司 2025-03-21 CN disclosed
CN-119504731-A Naringenin derivative containing 1,3, 4-oxadiazole acylhydrazone structure and preparation method thereof 广东省科学院测试分析研究所(中国广州分析测试中心) 2025-02-25 CN disclosed
US-20240300932-A1 N-PHENYLIMINE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF GUIZHOU UNIVERSITY (CN) 2024-09-12 US disclosed
CN-114466850-B [1,2,4] Triazolo [1,5-C ] quinazolin-5-amine 拜耳股份有限公司 2024-09-10 CN disclosed
US-5334726-A Controlling weeds ROHM AND HAAS COMPANY (US) 1994-08-02 US disclosed
US-5120347-A Pre and postemergence ROHM AND HAAS COMPANY (US) 1992-06-09 US disclosed
EP-0217748-B1 2-Substituted-e-fused-[1,2,4,]triazolo-[1,5-c]pyrimidines pharmaceutical compositions and uses thereof CIBA-GEIGY AG (CH) 1991-02-06 EP disclosed
US-4831013-A BENZODIAZEPINE RECEPTOR ANTAGONISTS CIBA-GEIGY CORPORATION (US) 1989-05-16 US disclosed
WO-1988002370-A1 2-SUBSTITUTED-E-FUSED-[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINES PHARMACEUTICAL COMPOSITIONS AND USES THEREOF CIBA-GEIGY AG (CH) 1988-04-07 WO disclosed
EP-0263071-A1 2-Substituted-e-fused-[1,2,4]-triazolo[1,5-c] pyrimidines, pharmaceutical compositions, and uses thereof CIBA-GEIGY AG (CH) 1988-04-06 EP disclosed
EP-0217748-A2 2-Substituted-e-fused-[1,2,4,]triazolo-[1,5-c]pyrimidines pharmaceutical compositions and uses thereof CIBA-GEIGY AG (CH) 1987-04-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240300932-A1 N-PHENYLIMINE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF PNMT, NNMT, PAH HDAC1 356/4885HDAC6 535/4885KDM4E 1931/4885
US-12338243-B2 P2X7 modulators P2RX7, P2RX4, P2RX1 HDAC1 4244/4885HDAC6 3629/4885KDM4E 4071/4885
US-10040741-B2 Method for manufacturing high purity glycol based compound GK, GMDS, UGCG HDAC1 1777/4885HDAC6 965/4885KDM4E 2823/4885
US-20160297732-A1 METHOD FOR MANUFACTURING HIGH PURITY GLYCOL BASED COMPOUND GK, GMDS, UGCG HDAC1 1777/4885HDAC6 965/4885KDM4E 2823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.