Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.57 |
| ▸ | CKS1B | P61024 | 1/20 | 0.57 |
| ▸ | SKP1 | P63208 | 1/20 | 0.57 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA4 | P22748 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 3/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401967 | 1.00 | GPR119 (0.58) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL649039 | 0.93 | CKS1B (0.65) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL30599874 | 0.90 | PDE10A (0.57) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL21227871 | 0.90 | PDE10A (0.57) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL239933 | 0.87 | GPR119 (0.63) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL18239342 | 0.85 | GPR119 (0.55) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL18228321 | 0.85 | GPR119 (0.59) | GPR119PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL17295995 | 0.85 | PDE10A (0.52) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL17295997 | 0.85 | PDE10A (0.52) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL7239787 | 0.84 | SYK (0.56) | PDE10ACKS1BSKP1SKP2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805181-B1 | PURINE DERIVATIVES FOR USE AS ADENOSIN A-2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2012-08-29 | — | — | EP | disclosed |
| US-8163754-B2 | inflammatory or obstructive airways diseases; in combination with an antiinflammatory, bronchodilatory, antihistamine or anti-tussive; N-[4-(6-Amino-2-phenethylamino-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-propionamide | NOVARTIS AG (CH) | 2012-04-24 | — | — | US | disclosed |
| EP-2292619-A1 | Purine derivatives for use as adenonsin A-2A receptor agonists | Novartis AG (CH) | 2011-03-09 | — | — | EP | disclosed |
| US-20090105476-A1 | Organic Compounds | NOVARTIS AG | 2009-04-23 | — | — | US | disclosed |
| US-20080200483-A1 | Purine Derivatives for Use as Adenosin A-2A Receptor Agonists | NOVARTIS AG (CH) | 2008-08-21 | — | — | US | disclosed |
| EP-1805181-A1 | PURINE DERIVATIVES FOR USE AS ADENOSIN A-2A RECEPTOR AGONISTS | Novartis AG (CH) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006045552-A1 | PURINE DERIVATIVES FOR USE AS ADENOSIN A-2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200483-A1 | Purine Derivatives for Use as Adenosin A-2A Receptor Agonists | ADORA2A, ADORA1, ADORA3 | GPR119 259/4885PDE10A 699/4885CKS1B 2055/4885 |
| US-20090105476-A1 | Organic Compounds | CYP3A43, SLCO1B3, CYP2C19 | GPR119 1142/4885PDE10A 1358/4885CKS1B 2652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.