Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
| ▸ | SUV39H2 | Q9H5I1 | 6/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | CKS1B | P61024 | 1/20 | 0.50 |
| ▸ | SKP1 | P63208 | 1/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.47 |
| ▸ | ITGAL | P20701 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29849700 | 0.88 | SUV39H2 (0.52) | SYKPDE10ASUV39H2MAP4K4CKS1B | |
| SCHEMBL7846512 | 0.86 | SYK (0.47) | SYKPDE10ASUV39H2MAP4K4CKS1B | |
| SCHEMBL1351791 | 0.86 | SYK (0.64) | SYKPDE10ASUV39H2MAP4K4CKS1B | |
| SCHEMBL1351789 | 0.86 | SYK (0.64) | SYKPDE10ASUV39H2MAP4K4CKS1B | |
| SCHEMBL7847483 | 0.86 | SYK (0.46) | SYKPDE10ASUV39H2MAP4K4CKS1B | |
| SCHEMBL20051576 | 0.85 | USP30 (0.58) | SYKPDE10ASUV39H2MAP4K4CKS1B | |
| SCHEMBL4278748 | 0.85 | GPBAR1 (0.47) | SYKITGB2ICAM1ITGAL | |
| SCHEMBL18228315 | 0.84 | PDE10A (0.55) | SYKPDE10ASUV39H2MAP4K4CKS1B | |
| SCHEMBL1401964 | 0.84 | GPR119 (0.58) | SYKPDE10AMAP4K4CKS1BSKP1 | |
| SCHEMBL1401967 | 0.84 | GPR119 (0.58) | SYKPDE10AMAP4K4CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |