Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 6/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788342 | 0.90 | CRHR1 (0.46) | MAPTMAPK8MAPK9KDM4EMAPK1 | |
| SCHEMBL4789197 | 0.88 | CNR1 (0.43) | MAPTMAPK8MAPK9KDM4EMAPK1 | |
| SCHEMBL4751343 | 0.87 | TDP2 (0.41) | MAPTMAPK8MAPK9KDM4EMAPK1 | |
| SCHEMBL4788229 | 0.87 | MAPT (0.39) | MAPTMAPK8MAPK9KDM4EMAPK1 | |
| SCHEMBL4787160 | 0.84 | MAPT (0.45) | MAPTKDM4EMAPK1CNR1CNR2 | |
| SCHEMBL4786903 | 0.84 | CNR1 (0.43) | CNR1CNR2KMT2ACYP2C9CYP2C19 | |
| SCHEMBL14020279 | 0.82 | MAPT (0.43) | MAPTKDM4EMAPK1CNR1CNR2 | |
| SCHEMBL4787973 | 0.79 | CNR1 (0.47) | MAPTKDM4EMAPK1CNR1CNR2 | |
| SCHEMBL1753008 | 0.76 | MAPT (0.69) | MAPTKDM4EMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL1689384 | 0.75 | GRM1 (0.47) | MAPTKDM4EMAPK1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134300-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-11-06 | — | — | WO | disclosed |